Cystadane - betaine anhydrous - For a future, for a life






Welcome to the Cystadane® website.  Cystadane® is a methylating agent indicated for the treatment of homocystinuria to decrease elevated homocysteine blood levels.

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Cystadane® can be ordered in the USA through AnovoRx Distribution, LLC and AnovoRx Group, LLC (AnovoRx Distribution, LLC, is the authorized distributor of record for CystadaneŽ).

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Cystadane® is a methylating agent indicated for the treatment of homocystinuria to decrease elevated homocysteine blood levels. Included within the category of homocystinuria are deficiencies or defects in:

  1. cystathionine beta-synthase (CBS),
  2. 5,10-methylenatetrahydrofolate reductase (MTHFR),
  3. cobalamin cofactor metabolism (cbl).

Patient response to Cystadane® can be monitored by homocysteine plasma levels (see DOSAGE AND ADMINISTRATION).  Response usually occurs within a week and steady state within a month.

Cystadane® has been administered concomitantly with vitamin B6 (pyridoxine), vitamin B12 (cobalamin), and folate.*

IMPORTANT SAFETY INFORMATION

The most serious adverse reaction reported with Cystadane® treatment is the development of hypermethioninemia and cerebral edema in patients with CBS Deficiency.*

In a survey study of physicians who had treated a total of 111 homocystinuria patients with Cystadane®, the types of adverse effects and the number of patients experiencing them were as follows:
Nausea (2), GI distress (2), Diarrhea (1), Bad taste (1), Caused odor (1), Questionable psychological changes (1), Aspirated the powder (1).*

*See Package Insert